Data sharing through ClinVar allows ongoing (a) inter-laboratory quality control, (b) detailed peer review, and (c) consensus interpretation for each and every variant classification by the global community of experts. Invitae submits data per recommendations of the American Medical Association (AMA), the National Society of Genetic Counselors (NSGC), and other groups.
These public data are essential for ongoing quality improvement in personalized medicine. Expert variant curation teams have now been set up by the ClinGen consortium, which are reviewing ClinVar classifications in their respective areas of expertise. Not only do these teams work towards consensus interpretation (particularly in cases where there is disagreement) but also they use this information to help improve variant interpretation guidelines for the entire medical genetics community.