Invitae’s team of scientists, physicians, and genetic counselors works together to provide high-quality and rigorous variant classifications. Invitae’s method of variant classification is a systematic process for assessing the evidence gathered during variant review and applying a formal variant classification based on this evidence. Our method of variant classification adheres closely to the recommendations from the American College of Medical Genetics (ACMG). These guidelines for variant interpretation represent the industry standard among clinical genetic testing laboratories. To learn more, visit our Variant Classification page.